Is Celecoxib compatible with breastfeeding? Do we have alternatives for Celecoxib?
Celecoxib
July 1, 2015 (Very Low Risk)
Indicated for treatment of Arthritis, Arthrosis and Gout. Acts by blocking cyclooxygenase enzyme (COX-2)
The amount of drug excreted into breast milk is so low that even trace amounts have not been found in blood sera of breastfed infant from treated mothers.
Alternatives
- Ibuprofen (Very Low Risk)
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Writings
- سيليكوكسيب (Arabic)
- Целекоксиб (Cyrillic)
- 塞来考昔 (Chinese)
- セレコキシブ (Japanese)
Drug trade names
- Aclarex™
- Artilog™
- Aubrex™
- Celcoxx™
- Celebra™
- Celebrex (Целебрекс)™
- Celebrex (西乐葆)™
- Celebrex™
- Celexib™
- Cexb™
- Coxbitor™
- Coxoral™
- Coxtenk™
- Coxzan™
- Dolcelox™
- Euroflam™
- Flamar™
- Flogoxib (Флогоксиб)™
- Lexib™
- Lincox™
- Radicacine™
- Ranselex (Ранселекс)™
- Reumoxib (Ревмоксиб)™
- Solexa™
- ДІЛАКСА®
- РАНСЕЛЕКС
- РЕВМОКСИБ
- ФЛОГОКСИБ-ЗДОРОВ'Я
- ЦЕЛЕБРЕКС®
- ЦЕЛЕКОКСИБ
References
- Reece-Stremtan Sarah, Campos Matilde, Kokajko Lauren, and The Academy of Breastfeeding Medicine. Breastfeeding Medicine. ABM Clinical Protocol #15: Analgesia and Anesthesia for the Breastfeeding Mother, Revised 2017. Breastfeeding Medicine. 2017 Full text (link to original source) Full text (in our servers)
- Götestam Skorpen C, Hoeltzenbein M, Tincani A, Fischer-Betz R, Elefant E, Chambers C, da Silva J, Nelson-Piercy C, Cetin I, Costedoat-Chalumeau N, Dolhain R, Förger F, Khamashta M, Ruiz-Irastorza G, Zink A, Vencovsky J, Cutolo M, Caeyers N, Zumbühl C, Østensen M. The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Ann Rheum Dis. 2016Abstract Full text (link to original source) Full text (in our servers)
- Noviani M, Wasserman S, Clowse ME. Breastfeeding in mothers with systemic lupus erythematosus. Lupus. 2016Abstract
- Matsota P, Nakou M, Kalimeris K, Batistaki C, Pandazi A, Kostopanagiotou G. A single dose of celecoxib 200 mg improves postoperative analgesia provided via patient-controlled epidural technique after caesarean section. Arch Med Sci. 2013Abstract Full text (link to original source) Full text (in our servers)
- Sachs HC; Committee On Drugs. The transfer of drugs and therapeutics into human breast milk: an update on selected topics. Pediatrics. 2013Abstract Full text (link to original source) Full text (in our servers)
- Ruhlen RL, Chen YC, Rottinghaus GE, Sauter ER. RE: \Transfer of celecoxib into human milk\. J Hum Lact. 2007Abstract
- Ruhlen RL, Chen YC, Rottinghaus GE, Sauter ER. RE: "Transfer of celecoxib into human milk". J Hum Lact. 2007Abstract
- Østensen M, Motta M. Therapy insight: the use of antirheumatic drugs during nursing. Nat Clin Pract Rheumatol. 2007Abstract
- Gardiner SJ, Doogue MP, Zhang M, Begg EJ. Quantification of infant exposure to celecoxib through breast milk. Br J Clin Pharmacol. 2006Abstract Full text (link to original source) Full text (in our servers)
- Hale TW, McDonald R, Boger J. Transfer of celecoxib into human milk. J Hum Lact. 2004Abstract
- Burdan F, Korobowicz A. [Coxibs: highly selective cyclooxygenase-2 inhibitors. Part II. Side effects]. Pol Merkur Lekarski. 2003Abstract
- Knoppert DC, Stempak D, Baruchel S, Koren G. Celecoxib in human milk: a case report. Pharmacotherapy. 2003Abstract