A second generation antihistamine, derived from piperazine and hydroxyzine metabolite, with minimal sedative effects and very low toxicity even at high doses.
No problems were detected in the short or long term in an infant whose mother took it during the first month after delivery as part of the treatment for pemphigus (Westermann 2012).
Its high binding to plasma proteins makes its transfer to milk very unlikely.
The British Society for Allergy and Clinical Immunology and other experts consider it safe during breastfeeding (Butler 2014, Powell 2007).
- Loratadine (Very Low Risk)
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
- Κετιριζίνη υδροχλωρική (Greek)
- Цетиризина Гидрохлорид (Cyrillic)
- セチリジン塩酸塩 (Japanese)
- Cétirizine, Chlorhydrate de (French)
- C21H25ClN2O3,2HCl (Molecular formula)
- Dihydrochloride of 2-[4-(4-chlorobenzhydryl)piperazin-1-yl]ethoxyacetic acid (Chemical name)
- R06AE07 (ATC Code/s)
Drug trade names
- Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014Abstract
- Westermann L, Hügel R, Meier M, Weichenthal M, Zillikens D, Gläser R, Schmidt E. Glucocorticosteroid-resistant pemphigoid gestationis: successful treatment with adjuvant immunoadsorption. J Dermatol. 2012Abstract
- Powell RJ, Du Toit GL, Siddique N, Leech SC, Dixon TA, Clark AT, Mirakian R, Walker SM, Huber PA, Nasser SM; British Society for Allergy and Clinical Immunology (BSACI). BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy. 2007Abstract Full text (link to original source) Full text (in our servers)