Is Chlorzoxazone compatible with breastfeeding? Do we have alternatives for Chlorzoxazone?

Chlorzoxazone

October 11, 2017 (High Risk)

Centrally-acting muscle relaxant with sedative properties. Administered orally.
It has pharmacokinetics with rapid absorption and elimination (PDR 2017, Prompila 2007, Desiraju 1983).

Since the last update we have not found published data about its excretion in breast milk.

Its pharmacokinetic data (low molecular weight, low protein binding, small volume of distribution) make its likely that it could pass into breast milk in quantities that could be significant.

If you have to use it during breastfeeding, you should monitor sedative effects in the baby. To minimize exposure, medication can be taken just after a feed and waiting 3-4 hours before breastfeeding again.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • كلورزوكسازون (Arabic)
  • Хлорзоксазон (Cyrillic)
  • 氯唑沙宗 (Chinese)
  • クロルゾキサゾン (Japanese)
  • Chlorzoxazone (French)
  • C7H4ClNO2 (Molecular formula)
  • 5-Chlorobenzoxazol-2(3H)-one (Chemical name)
  • M03BB03 (ATC Code/s)

Drug trade names

References

  1. PDR. Chlorzoxazone (Lorzone). Drug Summary. 2017 Full text (link to original source) Full text (in our servers)
  2. Prompila N, Wittayalertpanya S, Komolmit P. A study on the pharmacokinetics of chlorzoxazone in healthy Thai volunteers. J Med Assoc Thai. 2007Abstract
  3. Desiraju RK, Renzi NL Jr, Nayak RK, Ng KT. Pharmacokinetics of chlorzoxazone in humans. J Pharm Sci. 1983Abstract