Choriogonadotropin Alfa
It is the synthetic form of the natural human chorionic gonadotropin (hCG) hormone, produced by recombinant DNA technology.
Administration by subcutaneous injection.
Indicated to stimulate ovulation in assisted reproduction techniques.
Since the last update we have not found published data on its excretion in breastmilk.
Its high molecular weight makes it very unlikely it will transfer into milk in significant quantities.
Due to its protein nature it is inactivated in the gastrointestinal tract, not being absorbed, so its oral bioavailability is practically nil, except in premature babies and the immediate neonatal period when there may be greater intestinal permeability.
May cause increased prolactin and galactorrhea (Mendes 2001).
No adverse effects have been recorded in infants.
In infertility treatments, the possible theoretical anovulatory effect of frequent on demand breastfeeding must be taken into account.
See below the information of these related products:
- Human Chorionic Gonadotrophin (Low Risk probable)
- Human Menopausal Gonadotrophins (Low Risk probable)
- Lutropin (Low Risk probable)
Alternatives
We do not have alternatives for Choriogonadotropin Alfa.
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Synonyms
- Chorionic Gonadotrophin Alpha
Writings
- Χοριονική γοναδοτροπίνη άλφα (Greek)
- كوريوغونادوتروبين ألفا (Arabic)
- Хориогонадотропин Альфа (Cyrillic)
- 绒促性素α (Chinese)
- コリオゴナドトロピンアルファ (Japanese)
- C1105 H1770 N318 O336 S26 (Molecular formula)
- G03GA08 (ATC Code/s)
Drug trade names
References
- EMA. Coriogonadotropina alfa (Ovitrelle). Ficha técnica. 2017 Full text (in our servers)
- EMA. Choriogonadotropin alfa (Ovitrelle). Drug Summary 2017 Full text (in our servers)
- Mendes MC, Ferriani RA, Sala MM, Moura MD, Carrara HH, de Sá MF. Effect of transitory hyperprolactinemia on in vitro fertilization of human oocytes. J Reprod Med. 2001Abstract