Is Choriogonadotropin Alfa compatible with breastfeeding? Do we have alternatives for Choriogonadotropin Alfa?

Choriogonadotropin Alfa

June 10, 2018 (Low Risk)

It is the synthetic form of the natural human chorionic gonadotropin (hCG) hormone, produced by recombinant DNA technology.
Administration by subcutaneous injection.
Indicated to stimulate ovulation in assisted reproduction techniques.

Since the last update we have not found published data on its excretion in breastmilk.

Its high molecular weight makes it very unlikely it will transfer into milk in significant quantities.

Due to its protein nature it is inactivated in the gastrointestinal tract, not being absorbed, so its oral bioavailability is practically nil, except in premature babies and the immediate neonatal period when there may be greater intestinal permeability.

May cause increased prolactin and galactorrhea (Mendes 2001).

No adverse effects have been recorded in infants.

In infertility treatments, the possible theoretical anovulatory effect of frequent on demand breastfeeding must be taken into account.


See below the information of these related products:

Alternatives

We do not have alternatives for Choriogonadotropin Alfa.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Chorionic Gonadotrophin Alpha

Writings

  • Χοριονική γοναδοτροπίνη άλφα (Greek)
  • كوريوغونادوتروبين ألفا (Arabic)
  • Хориогонадотропин Альфа (Cyrillic)
  • 绒促性素α (Chinese)
  • コリオゴナドトロピンアルファ (Japanese)
  • C1105 H1770 N318 O336 S26 (Molecular formula)
  • G03GA08 (ATC Code/s)

References

  1. EMA. Coriogonadotropina alfa (Ovitrelle). Ficha técnica. 2017 Full text (in our servers)
  2. EMA. Choriogonadotropin alfa (Ovitrelle). Drug Summary 2017 Full text (in our servers)
  3. Mendes MC, Ferriani RA, Sala MM, Moura MD, Carrara HH, de Sá MF. Effect of transitory hyperprolactinemia on in vitro fertilization of human oocytes. J Reprod Med. 2001Abstract