Is Diazepam compatible with breastfeeding? Do we have alternatives for Diazepam?
Diazepam
May 23, 2015 (Low Risk)
It is a long-acting Benzodiazepine.
Low excreted into breast milk. However, it may cause sedation and poor suction reflex in the infant mostly because of large or repetitive use in the newborn period.
Low dose and short-term use is usually compatible with breastfeeding.
Choose a short-acting and minimal effective drug dose specially when nursing a newborn.
Watch out for somnolence and poor feeding of the infant.
Bed-sharing is not recommended for mothers who are taking this medication.
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Drug trade names
- Alboral™
- Aliseum™
- Aneurol™
- Ansilive™
- Ansiolin™
- Antenex™
- Anxicalm™
- Apaurin™
- Apollonset™
- Apozepam™
- Arzepam™
- Atarviton™
- Azepam™
- Benzopin™
- Benzyme™
- Betapam™
- Bialzepam™
- Calmociteno™
- Calmpose™
- Compaz™
- Complutine™
- Cuadel™
- D-Pam™
- Daiv™
- Dezepan™
- Diactal™
- Dialar™
- Diano™
- Diapam™
- Diapanil™
- Diapine™
- Diapo™
- Diastat™
- Diazefast™
- Diazemuls™
- Diazepan™
- Diazep™
- Dienpax™
- Dipezona™
- Dizan™
- Dizepam™
- Doval™
- Ducene™
- Elcion™
- Fabotranil™
- Faustan™
- Gewacalm™
- Gobanal™
- Hexalid™
- Kiatrium™
- Kratium™
- Lamra™
- Laxyl™
- Lembrol™
- Letansil™
- Medipam™
- Metamidol™
- Meval™
- Micronoan™
- Noan™
- Novazam™
- Onapan™
- Ortopsique™
- Paceum™
- Pacinax™
- Pacium™
- Pax™
- Paxum™
- Pazolini™
- Placidox™
- Plidan™ (Argentina)
- Prizem™
- Propam™
- Psychopax™
- Rec-DZ™
- Relanium™
- Relium™
- Rimapam™
- Saromet™
- Seduxen™
- Sicorelax™
- Sipam™
- Somaplus™
- Stedon™
- Stesolid™
- Talema™
- Telsomet™
- Tensium™ (Romania)
- Tranquirit™
- Umbrium™
- Uni Diazepax™
- Unisedil™
- Valaxona™
- Valclair™
- Valiquid™
- Valium™
- Valpam™
- Vatran™
- Vetansil™
- Vincosedan™
- Vival™
- Zepan™
- Zepose™
- Zeprat™
- Zopam™
- ДИАЗЕПЕКС®
- ДІАЗЕПАМ
- ДІАЗЕПАМ-ЗН
- РЕЛАНІУМ®
- СИБАЗОН
References
- Grover S, Avasthi A. Mood stabilizers in pregnancy and lactation. Indian J Psychiatry. 2015Abstract Full text (link to original source) Full text (in our servers)
- Davanzo R, Dal Bo S, Bua J, Copertino M, Zanelli E, Matarazzo L. Antiepileptic drugs and breastfeeding. Ital J Pediatr. 2013Abstract Full text (link to original source) Full text (in our servers)
- UNICEF UK Baby Friendly Initiative statement on Bed-sharing when parents do not smoke: is there a risk of SIDS? An individual level analysis of five major case-control studies. 2013 Full text (link to original source) Full text (in our servers)
- Sachs HC; Committee On Drugs. The transfer of drugs and therapeutics into human breast milk: an update on selected topics. Pediatrics. 2013Abstract Full text (link to original source) Full text (in our servers)
- Kelly LE, Poon S, Madadi P, Koren G. Neonatal benzodiazepines exposure during breastfeeding. J Pediatr. 2012Abstract
- Rapcencu AE, Lindhout D, Bulk S. Frequently asked questions on epilepsy, pregnancy and lactation: a EURAP-NL report. Seizure. 2012Abstract Full text (link to original source) Full text (in our servers)
- L.Landa Rivera, M.Díaz-Gómez, A.Gómez Papi, J.M.Paricio Talayero, C.Pallás Alonso, M.T.Hernández Aguilar, J.Aguayo Maldonado, J.M.Arena Ansotegui, S.Ares Segura, A.Jiménez Moya, J.J.Lasarte Velillas, J.Martín Calama, M.D.Romero Escós. El colecho favorece la práctica de la lactancia materna y no aumenta el riesgo de muerte súbita del lactante. Dormir con los padres. Rev Pediatr Aten Primaria. 14:53-60 2012 Full text (link to original source) Full text (in our servers)
- Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011Abstract Full text (link to original source) Full text (in our servers)
- ABM - Comité de protocolos de la Academia médica de lactancia materna (Academy of Breastfeeding Medicine). Protocolo Clínico de la ABM #6: Lineamientos sobre la práctica de dormir al bebé junto con la madre y la lactancia materna Revisión, marzo de 2008. Breastfeeding Medicine 2008 Full text (link to original source) Full text (in our servers)
- ABM - The Academy of Breastfeeding Medicine Protocol Committee. ABM Clinical Protocol #6: Guideline on Co-Sleeping and Breastfeeding. Breastfeeding Medicine 2008Abstract Full text (link to original source) Full text (in our servers)
- UNICEF UK. Compartiendo la cama con tu bebé. Guía para madres que amamantan. Folleto 2006 Full text (in our servers)
- Rubin ET, Lee A, Ito S. When breastfeeding mothers need CNS-acting drugs. Can J Clin Pharmacol. 2004Abstract
- Iqbal MM, Sobhan T, Ryals T. Effects of commonly used benzodiazepines on the fetus, the neonate, and the nursing infant. Psychiatr Serv. 2002Abstract Full text (in our servers)
- WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
- Hägg S, Spigset O. Anticonvulsant use during lactation. Drug Saf. 2000Abstract
- Borgatta L, Jenny RW, Gruss L, Ong C, Barad D. Clinical significance of methohexital, meperidine, and diazepam in breast milk. J Clin Pharmacol. 1997Abstract
- McElhatton PR. The effects of benzodiazepine use during pregnancy and lactation. Reprod Toxicol. 1994Abstract
- Lee JJ, Rubin AP. Breast feeding and anaesthesia. Anaesthesia. 1993Abstract Full text (link to original source) Full text (in our servers)
- Dusci LJ, Good SM, Hall RW, Ilett KF. Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam. Br J Clin Pharmacol. 1990Abstract Full text (in our servers)
- Wesson DR, Camber S, Harkey M, Smith DE. Diazepam and desmethyldiazepam in breast milk. J Psychoactive Drugs. 1985Abstract
- Kanto JH. Use of benzodiazepines during pregnancy, labour and lactation, with particular reference to pharmacokinetic considerations. Drugs. 1982Abstract
- Brandt R. Passage of diazepam and desmethyldiazepam into breast milk. Arzneimittelforschung. 1976Abstract
- Cole AP, Hailey DM. Diazepam and active metabolite in breast milk and their transfer to the neonate. Arch Dis Child. 1975Abstract Full text (in our servers)
- Kanto J, Erkkola R, Sellman R. Letter: Perinatal metabolism of diazepam. Br Med J. 1974Abstract Full text (in our servers)
- Patrick MJ, Tilstone WJ, Reavey P. Diazepam and breast-feeding. Lancet. 1972Abstract
- Erkkola R, Kanto J. Diazepam and breast-feeding. Lancet. 1972Abstract