Dimetindene Maleate (Topical use)
First generation antihistamine, alkylamine, with sedative and antimuscarinic effect.
It is used in the form of gel or cream for itchy skin relief.
At latest update no published data on excretion into breast milk was found.
Because a low dermal absorption and high plasma protein binding capacity, the passage of a significant amount into breast milk is unlikely.
Do not apply on the chest to prevent ingestion by the infant; otherwise, apply it after having nursed the infant and rinse it thoroughly with water before the next feeding.
Avoid applying creams, gels and other local application product containing paraffin to the nipple (mineral oil) for the infant not absorbed.
The systemic use (oral, nasal or intravenous inhalation) during breastfeeding
is considered to risky. See Dimethindene maleate (systemic use)
See below the information of this related product:
- Dimetindene Maleate (systemic use) (High Risk probable)
Alternatives
We do not have alternatives for Dimetindene Maleate (Topical use) since it is relatively safe.
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Synonyms
- Dimethindene Maleate (Topical use)
Writings
- Διμενθιδένη μηλεϊνική (topical) (Greek)
- Диметиндена Малеат (topical) (Cyrillic)
- マレイン酸ジメチンデン (topical) (Japanese)
- C20H24N2,C4H4O4 (topical) (Molecular formula)
Drug trade names
References
- Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008Abstract
- Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003Abstract
- AEMPS. Dimetindeno emulsión Ficha técnica. 2000 Full text (in our servers)
- Radler S, Blaschke G. Transdermal absorption of dimethindene in man. Arch Pharm (Weinheim). 1995Abstract
- Arnera V, Wermeille M, Wellman M, Llull JB, Althaus MA, Balant LP. Pharmacokinetics of dimetindene after intravenous and oral administration to healthy volunteers. Arzneimittelforschung. 1990Abstract