Is Dimetindene Maleate (systemic use) compatible with breastfeeding? Do we have alternatives for Dimetindene Maleate (systemic use)?

Dimetindene Maleate (systemic use)

July 15, 2017 (High Risk)

First generation antihistamine drug which is derived from ethylene diamine with important sedative and antimuscarinic effects.

At latest update no published data on excretion into breast milk was found.
Inhibition of breastfeeding in the first weeks after birth due to an antiprolactin effect may appear.
For both the mother and the infant it would be safer taking antihistamines with proven safety and without sedative effect, especially in case of premature babies and infants under 1 month of age.

Otherwise when used during lactation, take the lowest effective dose but avoiding a prolonged use. Follow-up the baby for drowsiness and feeding issues.
It is not recommended to share a bed with your baby if you are taking this medicine.

The topical use as a gel or cream is compatible with breastfeeding. Do not apply on the chest. See Dimethindene Maleate (topical).


See below the information of this related product:

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Dimethindene Maleate

Writings

  • Διμενθιδένη μηλεϊνική (Greek)
  • Диметиндена Малеат (Cyrillic)
  • マレイン酸ジメチンデン (Japanese)
  • C20H24N2,C4H4O4 (Molecular formula)

Drug trade names

References

  1. UNICEF UK Baby Friendly Initiative statement on Bed-sharing when parents do not smoke: is there a risk of SIDS? An individual level analysis of five major case-control studies. 2013 Full text (link to original source) Full text (in our servers)
  2. L.Landa Rivera, M.Díaz-Gómez, A.Gómez Papi, J.M.Paricio Talayero, C.Pallás Alonso, M.T.Hernández Aguilar, J.Aguayo Maldonado, J.M.Arena Ansotegui, S.Ares Segura, A.Jiménez Moya, J.J.Lasarte Velillas, J.Martín Calama, M.D.Romero Escós. El colecho favorece la práctica de la lactancia materna y no aumenta el riesgo de muerte súbita del lactante. Dormir con los padres. Rev Pediatr Aten Primaria. 14:53-60 2012 Full text (link to original source) Full text (in our servers)
  3. ABM - Comité de protocolos de la Academia médica de lactancia materna (Academy of Breastfeeding Medicine). Protocolo Clínico de la ABM #6: Lineamientos sobre la práctica de dormir al bebé junto con la madre y la lactancia materna Revisión, marzo de 2008. Breastfeeding Medicine 2008 Full text (link to original source) Full text (in our servers)
  4. ABM - The Academy of Breastfeeding Medicine Protocol Committee. ABM Clinical Protocol #6: Guideline on Co-Sleeping and Breastfeeding. Breastfeeding Medicine 2008Abstract Full text (link to original source) Full text (in our servers)
  5. UNICEF UK. Compartiendo la cama con tu bebé. Guía para madres que amamantan. Folleto 2006 Full text (in our servers)
  6. Radler S, Blaschke G. Transdermal absorption of dimethindene in man. Arch Pharm (Weinheim). 1995Abstract
  7. Arnera V, Wermeille M, Wellman M, Llull JB, Althaus MA, Balant LP. Pharmacokinetics of dimetindene after intravenous and oral administration to healthy volunteers. Arzneimittelforschung. 1990Abstract