Is Dipotassium Clorazepate compatible with breastfeeding? Do we have alternatives for Dipotassium Clorazepate?

Dipotassium Clorazepate

May 19, 2017 (Low Risk)

Long-acting benzodiazepine.

Most of the clorazepate is metabolized to N-desmethyldiazepam (nordiazepam) which is the active metabolite of diazepam.

It is excreted in breast milk in clinically insignificant amounts (Rey 1979).

Sedation has been observed in infants whose mothers were taking diazepam (Wesson 1985).

Due to the lack of publications on this subject, until more information is known about this drug in relation to breastfeeding, safer known alternatives are preferred, especially in the neonatal period and in case of prematurity (McElhatton 1994).

Occasional and low-dose use of benzodiazepines is compatible with breastfeeding. It is advisable to choose short-duration benzodiazepines and to use the minimum effective dose. Monitor drowsiness and the adequate feeding of the infant (Kanto 1982).

It is not recommended to co-sleep with the baby if you are taking this medication (UNICEF 2013, Landa 2012, ABM 2008, UNICEF 2006).

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Clorazepate" Monopotassium
  • Clorazepic Acid

Writings

  • κλοραζεπάτη καλιούχος (Greek)
  • كلورازيبات ديبوتاسيوم (Arabic)
  • Дикалия Клоразепат (Cyrillic)
  • 氯迨酸钾 (Chinese)
  • クロラゼプ酸二カリウム (Japanese)
  • C16H11ClK2N2O4 (Molecular formula)

Drug trade names

References

  1. UNICEF UK Baby Friendly Initiative statement on Bed-sharing when parents do not smoke: is there a risk of SIDS? An individual level analysis of five major case-control studies. 2013 Full text (link to original source) Full text (in our servers)
  2. L.Landa Rivera, M.Díaz-Gómez, A.Gómez Papi, J.M.Paricio Talayero, C.Pallás Alonso, M.T.Hernández Aguilar, J.Aguayo Maldonado, J.M.Arena Ansotegui, S.Ares Segura, A.Jiménez Moya, J.J.Lasarte Velillas, J.Martín Calama, M.D.Romero Escós. El colecho favorece la práctica de la lactancia materna y no aumenta el riesgo de muerte súbita del lactante. Dormir con los padres. Rev Pediatr Aten Primaria. 14:53-60 2012 Full text (link to original source) Full text (in our servers)
  3. Normon. Clorazepato Ficha técnica. 2011 Full text (in our servers)
  4. Abbott. Clorazepate. Drug Summary. 2009 Full text (in our servers)
  5. ABM - Comité de protocolos de la Academia médica de lactancia materna (Academy of Breastfeeding Medicine). Protocolo Clínico de la ABM #6: Lineamientos sobre la práctica de dormir al bebé junto con la madre y la lactancia materna Revisión, marzo de 2008. Breastfeeding Medicine 2008 Full text (link to original source) Full text (in our servers)
  6. ABM - The Academy of Breastfeeding Medicine Protocol Committee. ABM Clinical Protocol #6: Guideline on Co-Sleeping and Breastfeeding. Breastfeeding Medicine 2008Abstract Full text (link to original source) Full text (in our servers)
  7. UNICEF UK. Compartiendo la cama con tu bebé. Guía para madres que amamantan. Folleto 2006 Full text (in our servers)
  8. McElhatton PR. The effects of benzodiazepine use during pregnancy and lactation. Reprod Toxicol. 1994Abstract
  9. Wesson DR, Camber S, Harkey M, Smith DE. Diazepam and desmethyldiazepam in breast milk. J Psychoactive Drugs. 1985Abstract
  10. Kanto JH. Use of benzodiazepines during pregnancy, labour and lactation, with particular reference to pharmacokinetic considerations. Drugs. 1982Abstract
  11. Rey E, Giraux P, d'Athis P, Turquais JM, Chavinie J, Olive G. Pharmacokinetics of the placental transfer and distribution of clorazepate and its metabolite nordiazepam in the feto-placental unit and in the neonate. Eur J Clin Pharmacol. 1979Abstract