Is Everolimus compatible with breastfeeding? Do we have alternatives for Everolimus?
Everolimus
January 21, 2014 (High Risk)
On latest update relevant data on breastfeeding was not found.
Pharmacokinetic data (high molecular weight but low protein binding) indicates that drug excretion into breast milk would be moderately high. Low oral biodisponibility would be protective for breastfed children who are not newborn or premature.
Until new data is available nursing should be delayed for a 5-half lives period (150 hours - 6 to 7 days) after last intake.
Alternatives
- Azathioprine (Very Low Risk)
- Ciclosporin (Very Low Risk)
- Tacrolimus (Very Low Risk)
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
References
- Constantinescu S, Pai A, Coscia LA, Davison JM, Moritz MJ, Armenti VT. Breast-feeding after transplantation. Best Pract Res Clin Obstet Gynaecol. 2014Abstract
- Everolimus Drug Summary 2013 Full text (in our servers)
- Everolimus Ficha técnica 2013 Full text (in our servers)