Is Glibenclamide compatible with breastfeeding? Do we have alternatives for Glibenclamide?

Glibenclamide

August 6, 2017 (Very Low Risk)

Sulfonylureas stimulate endogenous insulin secretion. They can cause hypoglycemia.

Its pharmacokinetic data (moderately high molecular weight and very high percentage of plasma protein binding) explain the zero or negligible passage into breast milk observed (Serrano 2014, Glatstein 2009, Feig 2007and 2005).

Although blood sugar levels were normal in an infant whose mother was taking glibencamide (Feig 2005), one author suggests monitoring for symptoms of hypoglycemia in the infant (Glatstein 2009).

List of WHO essential medicines: compatible with breastfeeding (WHO / UNICEF 2002).

Diet, exercise, and breastfeeding improve blood sugar levels.


See below the information of this related product:

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Glyburide

Writings

  • Γλιβενκλαμίδη (Greek)
  • غليبانكلاميد (Arabic)
  • Глибенкламид (Cyrillic)
  • 格列本脲 (Chinese)
  • グリベンクラミド (Japanese)
  • C23H28ClN3O5S (Molecular formula)

Drug trade names

References

  1. AEMPS. Glibenclamida. Ficha técnica. 2016 Full text (in our servers)
  2. Serrano Aguayo P, García de Quirós Muñoz JM, Bretón Lesmes I, Cózar León MV. Tratamiento de enfermedades endocrinológicas durante la lactancia. [Endocrinologic diseases management during breastfeeding.] Med Clin (Barc). 2015Abstract
  3. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. 2013Abstract
  4. Sanofi. Glibenclamide. Drug Summary. 2012 Full text (in our servers)
  5. Refuerzo JS. Oral hypoglycemic agents in pregnancy. Obstet Gynecol Clin North Am. 2011Abstract
  6. Glatstein MM, Djokanovic N, Garcia-Bournissen F, Finkelstein Y, Koren G. Use of hypoglycemic drugs during lactation. Can Fam Physician. 2009Abstract Full text (link to original source) Full text (in our servers)
  7. Feig DS, Briggs GG, Koren G. Oral antidiabetic agents in pregnancy and lactation: a paradigm shift? Ann Pharmacother. 2007Abstract
  8. Feig DS, Briggs GG, Kraemer JM, Ambrose PJ, Moskovitz DN, Nageotte M, Donat DJ, Padilla G, Wan S, Klein J, Koren G. Transfer of glyburide and glipizide into breast milk. Diabetes Care. 2005Abstract Full text (link to original source) Full text (in our servers)
  9. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)