Is Isometheptene compatible with breastfeeding? Do we have alternatives for Isometheptene?

Isometheptene

November 14, 2014 (High Risk)

Seemingly a sympathomimetic drug with poor effect on Migraine relief.

On latest update relevant data on breastfeeding was not found.

Because a low excretion into breast milk Sumatriptan is a preferred drug.

Other medication for Migraine relief like Triptans, Ibuprofen, Diclofenac and Ketorolate are more effective and at a lower risk for breastfeeding than Isometheptene.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Drug trade names

References

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  2. Jürgens TP, Schaefer C, May A. Treatment of cluster headache in pregnancy and lactation. Cephalalgia. 2009Abstract
  3. Marcus DA. Managing headache during pregnancy and lactation. Expert Rev Neurother. 2008Abstract
  4. Raña-Martínez N. [Migraine in females]. Rev Neurol. 2008Abstract
  5. Beseler-Soto B, Paricio-Talayero JM, Sánchez-Palomares M, Benlloch-Muncharaz M, Santos-Serrano L, Landa-Rivera L. [Migraine and female]. Rev Neurol. 2008Abstract
  6. MacGregor EA. Migraine in pregnancy and lactation: a clinical review. J Fam Plann Reprod Health Care. 2007Abstract Full text (in our servers)
  7. Loder E. Migraine in pregnancy. Semin Neurol. 2007Abstract
  8. Sances G, Granella F, Nappi RE, Fignon A, Ghiotto N, Polatti F, Nappi G. Course of migraine during pregnancy and postpartum: a prospective study. Cephalalgia. 2003Abstract
  9. Allais G, Bosio A, Mana O, Airola G, Ciochetto D, Terzi MG, De Lorenzo C, Quirico PE, Benedetto C. [Migraine during pregnancy and lactation: treatment of the acute attack and non-pharmacological prophylactic strategies]. Minerva Med. 2003Abstract
  10. Rathmell JP, Viscomi CM, Ashburn MA. Management of nonobstetric pain during pregnancy and lactation. Anesth Analg. 1997Abstract
  11. Wojnar-Horton RE, Hackett LP, Yapp P, Dusci LJ, Paech M, Ilett KF. Distribution and excretion of sumatriptan in human milk. Br J Clin Pharmacol. 1996Abstract