Is Naphazoline compatible with breastfeeding? Do we have alternatives for Naphazoline?


January 9, 2017 (High Risk)

Sympathomimetic drug that is topically used for treatment of nose or the eye.

On last update no relevant published data related to breastfeeding were found.

Nasal use: Avoid high dosing and do not use for longer than 3 days: as an adrenergic agonist drug it could be absorbed and a cause of side effects (vascular hypertension or hypotension, irritability, heart arrhythmia) in both the mother and the infant.
Long term maintained doses may decrease milk production.

Low risk in Ophthalmologic use: A small dose together with a low plama level of most nasal and ophthalmologic compounds make that a significant excretion into breast milk would be unlikely.


Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.


  • Naphazoline Hydrochloride


  • نافازولين (Arabic)
  • Нафазолин (Cyrillic)
  • 萘甲唑啉 (Chinese)
  • ナファゾリン (Japanese)


  1. Anderson PO. Decongestants and milk production. J Hum Lact. 2000Abstract
  2. Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000Abstract