Is Niflumic Acid compatible with breastfeeding? Do we have alternatives for Niflumic Acid?

Niflumic Acid

November 9, 2014 (Low Risk)

Active metabolite of Morniflumate.

At latest update, relevant information on excretion into breast milk was not found.

Due to a high serum-protein-binding capacity, excretion of Rabeprazole into breast milk in significant levels is unlikely.

Based on data offered by the manufacturer, excretion into breast milk is minimal, with a concentration in the milk which is one-hundredth less than plasma level.

Nevertheless, it would be prudent the use of anti-inflammatory drugs known to be safe while breastfeeding.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • モルニフルマート
  • Morniflumate
  • حمض نيفلوميك
  • مورنيفلومات
  • Морнифлумат
  • Нифлумовая Кислота
  • 吗尼氟酯
  • 尼氟酸
  • ニフルム酸

Drug trade names

References

  1. Azzouz A, Jurado-Sánchez B, Souhail B, Ballesteros E. Simultaneous determination of 20 pharmacologically active substances in cow's milk, goat's milk, and human breast milk by gas chromatography-mass spectrometry. J Agric Food Chem. 2011Abstract
  2. AEMPS. Ácido niflúmico. Ficha técnica 2009 Full text (in our servers)
  3. Alessandri JL, Abossolo T, Reynaud I, Montbrun A, Sommer JC, Tilmont P. [Non-steroidal anti-inflammatory agents and pregnancy. A study of renal and digestive toxicity of niflumic acid in the perinatal period]. J Gynecol Obstet Biol Reprod (Paris). 1994Abstract
  4. Chevallier B, Baudet V, Doumaz Y, Renaud C, Costil J. [Neonatal renal insufficiency secondary to niflumic acid administration in pregnancy]. Arch Fr Pediatr. 1992Abstract
  5. Houin G, Tremblay D, Bree F, Dufour A, Ledudal P, Tillement JP. The pharmacokinetics and availability of niflumic acid in humans. Int J Clin Pharmacol Ther Toxicol. 1983Abstract