Is Nitrendipine compatible with breastfeeding? Do we have alternatives for Nitrendipine?

Nitrendipine

June 4, 2016 (Very Low Risk)

It is excreted into breast milk in clinically non-significant amount possibly due to its high plasma protein binding capacity.

Evidence on other antihypertensive drugs of the same family with similar structure, pharmacokinetics and action profile (nifedipine, nimodipine, nicardipine) has shown that they are excreted into milk in non-significant amount.

Until more extensive published data about this drug regarding breastfeeding are available a safer alternative drug should be used, especially during the neonatal period and/or in case of premature infants.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • نيترانديبين (Arabic)
  • Нитрендипин (Cyrillic)
  • 尼群地平 (Chinese)
  • ニトレンジピン (Japanese)
  • C18H20N2O6 (Molecular formula)

Drug trade names

References

  1. AEMPS. Nitrendipino. Ficha técnica. 2010 Full text (in our servers)
  2. White WB, Yeh SC, Krol GJ. Nitrendipine in human plasma and breast milk. Eur J Clin Pharmacol. 1989Abstract
  3. Eichelbaum M, Mikus G, Mast V, Fischer C, Kuhlmann U, Machleidt C. Pharmacokinetics and pharmacodynamics of nitrendipine in healthy subjects and patients with kidney and liver disease. J Cardiovasc Pharmacol. 1988Abstract