Is Ofloxacin compatible with breastfeeding? Do we have alternatives for Ofloxacin?


January 17, 2016 (Very Low Risk)

It is excreted in breast milk in small quantities.

Quinolone-derived drugs are being used in neonates and young infants, without the appearance of side effects. They are barely excreted into the milk and the absorption in the child’s intestine is hampered by the presence of calcium in the milk.

As long as it is necessary the use of fluoroquinolones in a lactating mother, norfloxacin, ofloxacin and ciprofloxacin should be chosen since they reach lower levels in the milk.

Check-up the baby for occurrence of diarrhea, since a case of pseudomembranous colitis was published possibly related to maternal intake of ciprofloxacin in a premature child who had suffered from necrotizing enterocolitis.

Take into account the possibility of negative-culture results in febrile infants whose mothers are on antibiotics.

American Academy of Pediatrics classifies it as usually compatible with breastfeeding medication.


Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.


  • οφλοξακίνη (Greek)
  • أوفلوكساسين (Arabic)
  • 氧氟沙星 (Chinese)
  • オフロキサシン (Japanese)
  • C18H20FN3O4 (Molecular formula)


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