Orphenadrine

Anti-muscarinic analogue agent similar to Diphenhydramine with no sedative effect. Used for the treatment of muscle spasms and Parkinson Disease.

At latest update, relevant published data on excretion into breast milk were not found.

Its pharmacokinetics (moderately high molecular weight and high protein-binding capacity) makes excretion into breast milk in significant amount be unlikely.

Until more data on this medication is available, safer alternative drugs are preferred especially in premature babies or during the neonatal period.

Whenever used while breastfeeding take the lowest dose as possible along with a follow-up for somnolence and troubles of the infant with feeding.

It is not commercially available in Spain.

Alternatives

• Baclofen (Very Low Risk)
• Methocarbamol (Low Risk probable)