Pyrazolone derivative analgesic that inhibits Prostaglandin synthesis with an increased risk of medullar aplasia.
Multiple compounds in association to caffeine, codeine, atropine and anti-inflammatory drugs are available.
Overall, multi-drug associated compounds are not recommended especially while nursing. A single drug product should be .preferred.
Ear drops containing this component are safe while nursing.
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
- Frei H, Bühlmann U, Rudin O. [Toxic hemolytic anemia in the newborn infant following ingestion of a phenazone derivative (Cibalgin) via breast milk]. Z Geburtshilfe Perinatol. 1985Abstract
- Berlin CM Jr, Vesell ES. Antipyrine disposition in milk and saliva of lactating women. Clin Pharmacol Ther. 1982Abstract