Is Phenazopyridine compatible with breastfeeding? Do we have alternatives for Phenazopyridine?


July 1, 2015 (Low Risk)

Azo dye with analgesic effect on the mucosa of the urinary tract. One of its metabolites is paracetamol. It can dye body secretions orange. Risk of methemoglobinemia.

At the date of last update, we did not find published data on its excretion in breast milk.

Poorly studied pharmacokinetic product with limited efficacy. Until more information about this drug is known, safer known alternatives are preferable, especially in the neonatal period and in case of prematurity or glucose-6PD deficiency.


Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.


  • NC-150
  • NSC-1879
  • Phenazopyridine Hydrochloride
  • W-1655


  • φαιναζοπυριδίνη υδροχλωρική (Greek)
  • Феназопиридина Гидрохлорид (Cyrillic)
  • 塩酸フェナゾピリジン (Japanese)


  1. Li KJ, Chen QH, Zhang Z, Zhou P, Li P, Liu J, Zhu J. Determination of phenazopyridine in human plasma by GC-MS and its pharmacokinetics. J Chromatogr Sci. 2008Abstract Full text (link to original source) Full text (in our servers)
  2. Gold NA, Bithoney WG. Methemoglobinemia due to ingestion of at most three pills of pyridium in a 2-year-old: case report and review. J Emerg Med. 2003Abstract