Piperidolate Hydrochloride

t is a tertiary amine with antimuscarinic/anticholinergic effects, with an action similar to atropine. It has smooth muscle antispasmodic properties. Administered for gastroenteritis, duodenal ulcer, biliary conditions, dysmenorrhea and treatment of miscarriage and premature birth (Kyorin 2013, Sanofi 2010).

Since the last update we have not found published data on its excretion in breast milk.

There is hardly any published scientific data on this product: there are only 6 studies and the most recent dates from 1977. There is no pharmacokinetic data except that it has good absorption in the digestive tract (Sanofi 2010). Other anticholinergics from the same family such as tolterodine have high protein binding, which would make it unlikely that it passes into milk in significant amounts. Atropine in isolated doses is considered compatible with breastfeeding.

During breastfeeding it may be prudent to avoid or take short-term and minimal doses, monitoring milk production as anticholinergics may reduce milk production (De Martino 1980, Bizarro 1980), especially the first few weeks postpartum. It is also advisable to monitor anticholinergic symptoms in the infant (dry mouth, constipation ..).

• Atropine (Very Low Risk)
• Tolterodine Tartrate (Low Risk probable)

Alternatives

• Otilonium Bromide (Very Low Risk)
• Atropine (Very Low Risk)