Propyphenazone

An analgesic derived from pyrazolone, inhibitor of prostaglandin synthesis by inhibiting cyclooxygenase.
Administered orally and rectally.

Since the last update date we have not found published data on its excretion in breastmilk.

Severe hemolytic anemia has been reported in a newborn whose mother was taking it (Frei 1985).

Since 1989, it has been withdrawn from sale in many countries for having caused medullary aplasia, Lyell's syndrome and other serious side effects (Onakpoya 2018).

It is marketed in multiple preparations that combine caffeine, codeine, atropine and anti-inflammatory drugs. In general, drug combinations are not recommended and even less so during breastfeeding.

Known alternatives which are safer during breastfeeding are preferred, especially during the neonatal period and in the case of prematurity.

Alternatives

• Ibuprofen (Very Low Risk)
• Paracetamol (Very Low Risk)
• Diclofenac (Very Low Risk)