Retinol
Retinol is also a name for vitamin A which is a natural component of human milk. Content in the human milk is about 2,800 IU/L (750 μ/L).
Infant's recommended dietary daily allowance is 2,000 IU (600 μ/L). Mother's recommended daily allowance is 3,200 IU (950 μ/L).
There is a risk for severe intoxication after an isolated dose of 25,000 IU or long-standing daily consumption of 5,000 IU.
After a megadose administration of vitamin A increases concentration to a double in the colostrum.
Supplementation with vitamin A to breastfeeding mothers or infants does not reduce mortality or morbidity among HIV affected offsprings, instead it increases the likelihood of transmission of HIV or subclinical mastitis in those mothers infected with HIV.
Vitamin A is widely distributed in the food of animal or vegetable origin. Except for populations affected with food shortage or nutritionally deficient, those women on a complete and varied diet do not need the intake of vitamin A supplementation
The List of Essential Medicines of WHO-2002 classifies it as compatible with breastfeeding.
Alternatives
We do not have alternatives for Retinol since it is relatively safe.
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Synonyms
- ビタミンA
- Antixerophthalmic Vitamin
- Axeroftol
- Vitamin A
- ريتينول
- βιταμίνη α
- ρετινόλη
- Ретинол
Drug trade names
- A-Vitel™
- Acon™
- Adermicina A Mama™
- Adermicina A Post Solar™
- Amenite A™
- Andrioderma™
- Aquasol A™
- Arovit™
- Atomoderma A-E™
- Atomoderma A™
- Augenschutz NA™
- Auxina A Masiva™
- Avitan™
- Biominol™
- Bioxilina™
- Dermotin A™
- Factor AE™
- Masivol™
- Microret™
- Multibionta Complex™
- Natalben Lactancia™
- Palmyforte™
- Pedi-Vit-A™
- Retigel-A™
- Rinocusi Vitaminico™
- Rinovitex™
- Ungvita™
- Videstim (Видестим)™
- Vita-POS (Вита-ПОС)™
- Vitafluid™
- Vitagel™
References
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- Grilo EC, Lima MS, Cunha LR, Gurgel CS, Clemente HA, Dimenstein R. Effect of maternal vitamin A supplementation on retinol concentration in colostrum. J Pediatr (Rio J). 2015Abstract
- Ares Segura S, Arena Ansótegui J, Díaz-Gómez NM; en representación del Comité de Lactancia Materna de la Asociación Española de Pediatría. La importancia de la nutrición materna durante la lactancia, ¿necesitan las madres lactantes suplementos nutricionales? [The importance of maternal nutrition during breastfeeding: Do breastfeeding mothers need nutritional supplements?] An Pediatr (Barc). 2015Abstract Full text (link to original source) Full text (in our servers)
- Greco CB, López LB, Rodríguez V, Dyner L, Gibson V, Pinotti LV, Ronayne de Ferrer PA. Comparison of vitamin A intake from breast milk and from complementary foods in the diet of six-month old infants in Jujuy and Buenos Aires. Arch Argent Pediatr. 2014Abstract
- Samba C, Tchibindat F, Gourmel B, Houzé P, Malvy D. Prevalence of vitamin A deficiency in pregnant and lactating women in the Republic of Congo. J Health Popul Nutr. 2013Abstract
- Fernandes TF, Figueiroa JN, Grande de Arruda IK, Diniz Ada S. Effect on infant illness of maternal supplementation with 400 000 IU vs 200 000 IU of vitamin A. Pediatrics. 2012Abstract
- de Pee S. Benefits of postpartum vitamin A supplementation. J Pediatr (Rio J). 2012Abstract
- Souza G, Saunders C, Dolinsky M, Queiroz J, Campos A, Ramalho A. Vitamin A concentration in mature human milk. J Pediatr (Rio J). 2012Abstract
- Wiysonge CS, Shey M, Kongnyuy EJ, Sterne JA, Brocklehurst P. Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection. Cochrane Database Syst Rev. 2011Abstract
- Gogia S, Sachdev HS. Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less. Cochrane Database Syst Rev. 2011Abstract
- Gogia S, Sachdev HS. Maternal postpartum vitamin A supplementation for the prevention of mortality and morbidity in infancy: a systematic review of randomized controlled trials. Int J Epidemiol. 2010Abstract
- Villamor E, Koulinska IN, Aboud S, Murrin C, Bosch RJ, Manji KP, Fawzi WW. Effect of vitamin supplements on HIV shedding in breast milk. Am J Clin Nutr. 2010Abstract
- Arsenault JE, Aboud S, Manji KP, Fawzi WW, Villamor E. Vitamin supplementation increases risk of subclinical mastitis in HIV-infected women. J Nutr. 2010Abstract
- Martins TM, Ferraz IS, Daneluzzi JC, Martinelli CE Jr, Del Ciampo LA, Ricco RG, Jordão AA Jr, Patta MC, Vannucchi H. Impact of maternal vitamin A supplementation on the mother-infant pair in Brazil. Eur J Clin Nutr. 2010Abstract
- Fisker AB. Comment on: 'Maternal postpartum vitamin A supplementation for the prevention of mortality and morbidity in infancy: a systematic review of randomised controlled trials'. Int J Epidemiol. 2010Abstract
- Oliveira-Menegozzo JM, Bergamaschi DP, Middleton P, East CE. Vitamin A supplementation for postpartum women. Cochrane Database Syst Rev. 2010Abstract
- van den Broek N, Dou L, Othman M, Neilson JP, Gates S, Gülmezoglu AM. Vitamin A supplementation during pregnancy for maternal and newborn outcomes. Cochrane Database Syst Rev. 2010Abstract
- Hall Moran V, Lowe N, Crossland N, Berti C, Cetin I, Hermoso M, Koletzko B, Dykes F. Nutritional requirements during lactation. Towards European alignment of reference values: the EURRECA network. Matern Child Nutr. 2010Abstract Full text (link to original source) Full text (in our servers)
- Ribeiro KD, Araújo KF, Dimenstein R. [The effect of vitamin A supplementation upon retinol concentration in the colostrum of women in a public maternity hospital]. Rev Assoc Med Bras. 2009Abstract
- de Azeredo VB, Trugo NM. Retinol, carotenoids, and tocopherols in the milk of lactating adolescents and relationships with plasma concentrations. Nutrition. 2008Abstract
- Israel-Ballard KA, Abrams BF, Coutsoudis A, Sibeko LN, Cheryk LA, Chantry CJ. Vitamin content of breast milk from HIV-1-infected mothers before and after flash-heat treatment. J Acquir Immune Defic Syndr. 2008Abstract
- Ahmed F, Azim A, Akhtaruzzaman M. Vitamin A deficiency in poor, urban, lactating women in Bangladesh: factors influencing vitamin A status. Public Health Nutr. 2003Abstract
- Dimenstein R, Simplício JL, Ribeiro KD, Melo IL. [Retinol levels in human colostrum: influence of child, maternal and socioeconomic variables]. J Pediatr (Rio J). 2003Abstract
- WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
- Christian P, West KP Jr, Khatry SK, Katz J, LeClerq SC, Kimbrough-Pradhan E, Dali SM, Shrestha SR. Vitamin A or beta-carotene supplementation reduces symptoms of illness in pregnant and lactating Nepali women. J Nutr. 2000Abstract
- Doran L, Evers S. Energy and nutrient inadequacies in the diets of low-income women who breast-feed. J Am Diet Assoc. 1997Abstract
- Reinersdorff DV, Bush E, Liberato DJ. Plasma kinetics of vitamin A in humans after a single oral dose of [8,9,19-13C]retinyl palmitate. J Lipid Res. 1996Abstract