Sibutramine
On latest update relevant published data on breastfeeding were not found.
Because of high protein-binding, excretion into breast milk seems unlikely.
Medication used as anorexigen. Amphetamine-like drug that acts as reuptake inhibitor of Serotonin, Norepinephrine and Dopamine. May cause increase of Prolactin and Galactorrhea.
Because of cardiovascular side effects (Arrhythmia, Hypertension, Heart infarction) several regulatory agencies (EMEA, FDA) have withdrawn it from the market in many countries.
Breastfeeding mothers return to their pre- pregnancy body weight sooner than others who don't.
Alternatives
- Hypo-Caloric Diet (Very Low Risk)
- Orlistat (Low Risk probable)
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Writings
- Сибутрамина (Cyrillic)
- シブトラミン (Japanese)
Drug trade names
- Aderan™
- Biomag™
- Ciplatrim™
- Downtrat™
- Ectiva™
- Fetrasil™
- Goldline (Голдлайн)™
- Ifa-Certez Duo™
- Ifa-Certez™
- Ipomex™
- Kifenip™
- Leptos™
- Lesfat™
- Lindaxa (Линдакса)™
- Maxislim™
- Meridia (Меридиа)™
- Meridia™
- Milical™
- Nobese™
- Nolipo™
- Obectiv™
- Obestat™
- Plenty™
- Reductil™
- Reduksin (Редуксин)™
- Redumed™
- Repentil™
- Saciette™
- Segusiv™
- Serotramin™
- Sibuctil™
- Sibus™
- Sibutran™
- Sigran (C1)™
- Siruton™
- Slenfig™
- Slimia (Слимия)™
- Vazy™
- Vintix™ (Venezuela)
References
- Soares Leaes CG, Pereira-Lima JF, da Costa Oliveira M. A case of sibutramine-induced hyperprolactinemia. Neuro Endocrinol Lett. 2011Abstract
- EMEA. European Medicines Agency recommends suspension of marketing authorisations for sibutramine. Press Office. 2010 Full text (link to original source) Full text (in our servers)
- FDA. FDA Recommends Against the Continued Use of Meridia (sibutramine). FDA Drug Safety Communication. 2010 Full text (link to original source) Full text (in our servers)
- MHRA (UK). Sibutramine: Suspension of marketing authorisation as risks outweigh benefits. Safety warnings and messages for medicines. 2010 Full text (link to original source) Full text (in our servers)
- Florakis D, Diamanti-Kandarakis E, Katsikis I, Nassis GP, Karkanaki A, Georgopoulos N, Panidis D. Effect of hypocaloric diet plus sibutramine treatment on hormonal and metabolic features in overweight and obese women with polycystic ovary syndrome: a randomized, 24-week study. Int J Obes (Lond). 2008Abstract Full text (link to original source) Full text (in our servers)
- Sibutramina. Ficha técnica. 2000 Full text (in our servers)
- Sibutramine. Drug Summary. 2000 Full text (in our servers)