Is Sodium Picosulfate compatible with breastfeeding? Do we have alternatives for Sodium Picosulfate?

Sodium Picosulfate

April 17, 2016 (Very Low Risk)

Stimulant of the intestine and laxative drug through irritation of mucosa which is similar to bisacodyl.

Its low oral bioavailability with minimal intestinal absorption causes plasma levels to be very low, that explains the observed failure of excretion into breast milk (undetectable levels).
Authorized for use in infants from age one month old.

To prevent or treat constipation is essential to have a balanced and fiber-rich diet, with a lot of fluids and exercise.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • νάτριο πικοθειϊκό (Greek)
  • بيكوسولفات صوديوم (Arabic)
  • Натрия Пикосульфат (Cyrillic)
  • 匹可硫酸钠 (Chinese)
  • ピコスルファートナトリウム (Japanese)
  • C18H13NNa2O8S2,H2O (Molecular formula)

Drug trade names

References

  1. Gharehbaghi K, Gharehbaghi DR, Wierrani F, Sliutz G. [Treatment of Chronic Functional Constipation during Pregnancy and Lactation]. Z Geburtshilfe Neonatol. 2016Abstract
  2. Müller-Lissner S. Pharmacokinetic and pharmacodynamic considerations for the current chronic constipation treatments. Expert Opin Drug Metab Toxicol. 2013Abstract
  3. Friedrich C, Richter E, Trommeshauser D, de Kruif S, van Iersel T, Mandel K, Gessner U. Absence of excretion of the active moiety of bisacodyl and sodium picosulfate into human breast milk: an open-label, parallel-group, multiple-dose study in healthy lactating women. Drug Metab Pharmacokinet. 2011Abstract Full text (link to original source) Full text (in our servers)