Is Thiocolchicoside compatible with breastfeeding? Do we have alternatives for Thiocolchicoside?

Thiocolchicoside

January 17, 2016 (High Risk)

Muscle-relaxant drug which is marketed in some countries and usually associated to acetaminophen.

At latest update no published data were found on excretion into breast milk.

Pharmacokinetic data favor excretion into breast milk.

Convulsions have been reported in susceptible persons. There is a warning on likely mutagenic effects with a prolonged use.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • ثيوكولشيكوزيد (Arabic)
  • Тиокольхикозид (Cyrillic)
  • 硫秋水仙苷 (Chinese)
  • チオコルチコシド (Japanese)
  • C27H33NO10S (Molecular formula)

Drug trade names

References

  1. AEMPS. Tiocolchicosido. Ficha técnica 2015 Full text (in our servers)
  2. EMA. La Agencia Europea de Medicamentos recomienda restringir el uso del tiocolchicósido por vía oral o inyectable. 2014 Full text (in our servers)
  3. EMA. Thiocolchicoside. Drug Summary. 2013 Full text (in our servers)
  4. EMA. European Medicines Agency recommends restricting use of thiocolchicoside by mouth or injection. 2013 Full text (in our servers)
  5. Giavina-Bianchi P, Giavina-Bianchi M, Tanno LK, Ensina LF, Motta AA, Kalil J. Epileptic seizure after treatment with thiocolchicoside. Ther Clin Risk Manag. 2009Abstract
  6. De Riu PL, Rosati G, Sotgiu S, Sechi G. Epileptic seizures after treatment with thiocolchicoside. Epilepsia. 2001Abstract
  7. Sandouk P, Chappey O, d'Yvoire MB, Scherrmann JM. Pharmacokinetics of thiocolchicoside in humans using a specific radioimmunoassay. Ther Drug Monit. 1995Abstract
  8. Perucca E, Poitou P, Pifferi G. Comparative pharmacokinetics and bioavailability of two oral formulations of thiocolchicoside, a GABA-mimetic muscle relaxant drug, in normal volunteers. Eur J Drug Metab Pharmacokinet. 1995Abstract
  9. Sandouk P, Bouvier d'Yvoire M, Chretien P, Tillement JP, Scherrmann JM. Single-dose bioavailability of oral and intramuscular thiocolchicoside in healthy volunteers. Biopharm Drug Dispos. 1994Abstract