Is Brompheniramine Maleate compatible with breastfeeding? Do we have alternatives for Brompheniramine Maleate?

Brompheniramine Maleate

February 15, 2016 (Low Risk)

First generation antihistamine, alkylamine drug, sedative with antimuscarinic effect.

Described irritability, crying and insomnia in a baby from a nursing mother after taking a preparation compounded by Iso-ephedrine and brompheniramine that were possibly responsible for the symptoms.
Check up the occurrence of drowsiness and inappropriate feeding of the infant.

Likely inhibition of breastfeeding in the first weeks after birth due to anti-prolactin effect.

It is not recommended bed-sharing with the baby if you are on this medication.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Dexbrompheniramine Maleate

Writings

  • Βρωμοφαινιραμίνη μηλεϊνική (Greek)
  • Бромфенирамина Малеат (Cyrillic)
  • マレイン酸ブロムフェニラミン (Japanese)
  • C16H19BrN2,C4H4O4 (Molecular formula)

Drug trade names

References

  1. UNICEF UK Baby Friendly Initiative statement on Bed-sharing when parents do not smoke: is there a risk of SIDS? An individual level analysis of five major case-control studies. 2013 Full text (link to original source) Full text (in our servers)
  2. L.Landa Rivera, M.Díaz-Gómez, A.Gómez Papi, J.M.Paricio Talayero, C.Pallás Alonso, M.T.Hernández Aguilar, J.Aguayo Maldonado, J.M.Arena Ansotegui, S.Ares Segura, A.Jiménez Moya, J.J.Lasarte Velillas, J.Martín Calama, M.D.Romero Escós. El colecho favorece la práctica de la lactancia materna y no aumenta el riesgo de muerte súbita del lactante. Dormir con los padres. Rev Pediatr Aten Primaria. 14:53-60 2012 Full text (link to original source) Full text (in our servers)
  3. ABM - Comité de protocolos de la Academia médica de lactancia materna (Academy of Breastfeeding Medicine). Protocolo Clínico de la ABM #6: Lineamientos sobre la práctica de dormir al bebé junto con la madre y la lactancia materna Revisión, marzo de 2008. Breastfeeding Medicine 2008 Full text (link to original source) Full text (in our servers)
  4. ABM - The Academy of Breastfeeding Medicine Protocol Committee. ABM Clinical Protocol #6: Guideline on Co-Sleeping and Breastfeeding. Breastfeeding Medicine 2008Abstract Full text (link to original source) Full text (in our servers)
  5. UNICEF UK. Compartiendo la cama con tu bebé. Guía para madres que amamantan. Folleto 2006 Full text (in our servers)
  6. Paton DM, Webster DR. Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines). Clin Pharmacokinet. 1985Abstract
  7. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977Abstract