Cinnarizine
A calcium channel blocker drug and an antihistamine piperazine derivative which has a sedative effect. Chemical structure and effects similar to Flunarizine (see specific info).
Used to treat nausea and vertigo of Meniere's Disease, and symptoms of Traveler´s Sickness.
It has been withdrawn from the market in several countries because of Parkinson-like symptoms.
At latest update relevant published data were not found on excretion into breast milk.
Its high binding capacity to plasma proteins makes it unlikely excretion into breastmilk.
It should be wise on the long-term, the use of a known safer alternative until more data is available on this drug, mostly for children in the neonatal period or in case of prematurity that may be affected by an increased gut permeability. Occasional use to prevent motion sickness may be compatible with breastfeeding.
See below the information of this related product:
- Flunarizine Hydrochloride (High Risk probable)
Alternatives
- Nimodipine (Very Low Risk)
- Ginkgo (Low Risk probable)
- Betahistine (Low Risk probable)
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Writings
- Κινναριζίνη (Greek)
- سيناريزين (Arabic)
- Циннаризин (Cyrillic)
- 桂利嗪 (Chinese)
- リ (Japanese)
- C26H28N2 (Molecular formula)
Drug trade names
References
- Davanzo R, Bua J, Paloni G, Facchina G. Breastfeeding and migraine drugs. Eur J Clin Pharmacol. 2014Abstract
- Teive HA, Troiano AR, Germiniani FM, Werneck LC. Flunarizine and cinnarizine-induced parkinsonism: a historical and clinical analysis. Parkinsonism Relat Disord. 2004Abstract
- Martí Massó JF, Carrera N, de la Puente E. [Parkinsonism possibly caused by cinnarizine]. Med Clin (Barc). 1985Abstract
- Paton DM, Webster DR. Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines). Clin Pharmacokinet. 1985Abstract