Is Etofenamate compatible with breastfeeding? Do we have alternatives for Etofenamate?

Etofenamate

April 16, 2015 (Low Risk)

It is a non-steroidal anti-inflammatory which is derived from Flufenamic acid, topically used but it can also be orally or intravenously administered.

At latest update relevant data related to breastfeeding were not found. However, we have information on its precursor the Flufenamic acid which is excreted into breast milk in non-significant amount and considered by the American Academy of Pediatrics as usual compatible with breastfeeding.

Absorption from skin to the plasma has been reported.

A high protein-binding capacity makes excretion into breast milk highly unlikely. However, it would be safer for both the mother and the infant the use of anti-inflammatory products with a proven safety while breastfeeding.

Avoid the use on the nipple or on extensive skin areas or long-term treatments to prevent systemic absorption.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • エトフェナマート
  • B-577; Bay-d-1107; TV-485; TVX-485; WHR-5020
  • إيتوفينامات
  • Этофенамат
  • 依托芬那酯

References

  1. Bayer. Etofenamato. Ficha técnica. 2011 Full text (in our servers)
  2. Bender T, Bariska J, Rojkovich B, Bálint G. Etofenamate levels in human serum and synovial fluid following iontophoresis. Arzneimittelforschung. 2001Abstract
  3. Herrera GL, Guevara LU, Torres GRA. Etofenamato: Características farmacologícas y clinicas de la formulación intramuscular. Rev Mex Anest 2001; 24 (4) 2001 Full text (link to original source) Full text (in our servers)
  4. Beckermann B, Bock E, Kamp R, Dell HD. [Plasma level studies in volunteers after intramuscular injection of various doses of etofenamate in an oily solution]. Arzneimittelforschung. 1990Abstract
  5. Dell HD, Beckermann B, Fiedler J, Kamp R. [Renal elimination and metabolism of etofenamate in volunteers after administration of various doses]. Arzneimittelforschung. 1990Abstract
  6. Dell HD, Fiedler J. [A test for excretion of etofenamate into milk]. Arch Pharm (Weinheim). 1983Abstract