Is Fexofenadine Hydrochloride compatible with breastfeeding? Do we have alternatives for Fexofenadine Hydrochloride?

Fexofenadine Hydrochloride

January 31, 2018 (Very Low Risk)

Antihistamine drug of 2nd generation, piperidine derivative, which is an active metabolite of Terfenadine with minimal sedative effect.
Oral administration twice a day.

It is excreted into breast milk in clinically non-significant amount (Butler 2014, So 2010, Leachman 2006, Lucas 1995).

On a telephone interview, 10% of infants whose mothers were on terfenadine, recognized to have experienced colicky pain and hyperexcitability that disappeared without treatment (Ito 1993).

American Academy of Pediatrics: medication usually compatible with breastfeeding (AAP 2001).


See below the information of this related product:

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • Φεξοφαιναδίνη Υδροχλωρική (Greek)
  • Фексофенадина Гидрохлорид (Cyrillic)
  • フェキソフェナジン塩酸塩 (Japanese)
  • C32 H39 NO4,HCl (Molecular formula)
  • (±)-p-{1-Hydroxy-4-[4-(hydroxydiphenylmethyl)-piperidino]butyl}-α-methylhydratropic acid hydrochloride (Chemical name)
  • R06AX26 (ATC Code/s)

Drug trade names

References

  1. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014Abstract
  2. Chen YA, Hsu KY. Pharmacokinetics of fexofenadine in healthy Taiwanese volunteers. Pak J Pharm Sci. 2014Abstract
  3. Fexofenadina. Ficha tecnica. 2013 Full text (in our servers)
  4. MHRA. Fexofenadine. Drug Summary. 2011 Full text (in our servers)
  5. So M, Bozzo P, Inoue M, Einarson A. Safety of antihistamines during pregnancy and lactation. Can Fam Physician. 2010Abstract Full text (link to original source) Full text (in our servers)
  6. Leachman SA, Reed BR. The use of dermatologic drugs in pregnancy and lactation. Dermatol Clin. 2006Abstract
  7. Solhaug V, Roland PD. Bruk av antihistaminer under graviditet og amming \ [Use of antihistaminics during pregnancy and breast feeding]. Tidsskr Nor Laegeforen. 2004Abstract Full text (link to original source) Full text (in our servers)
  8. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001Abstract Full text (link to original source) Full text (in our servers)
  9. Lucas BD Jr, Purdy CY, Scarim SK, Benjamin S, Abel SR, Hilleman DE. Terfenadine pharmacokinetics in breast milk in lactating women. Clin Pharmacol Ther. 1995Abstract
  10. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993Abstract