Lercanidipine Hydrochloride

At latest update no published data were found on excretion into breast milk.

Evidence on other antihypertensive drugs of the same family with similar structure, pharmacokinetics and action profile (nifedipine, nimodipine, nicardipine) has shown that they are excreted into milk in non-significant amount.
Its high plasma protein binding capacity makes it unlikely any passage to the milk, however, its high lipid solubility facilitates excretion into it.

Although it has a low oral bioavailability, it may increase to four times if administered with a fatty meal, which would increase the oral absorption in the infant.

Until more extensive published data about this drug regarding breastfeeding are available a safer alternative drug should be used, especially during the neonatal period and/or in case of premature infants.

Alternatives

• Nimodipine (Very Low Risk)
• Nifedipine (Very Low Risk)
• Verapamil Hydrochloride (Very Low Risk)