Is Mepyramine compatible with breastfeeding? Do we have alternatives for Mepyramine?

Mepyramine

October 9, 2016 (Low Risk)

First generation antihistamine with sedative and important antimuscarinic effects. Such remarkable anticholinergic effect may inhibit lactation.

At latest update no published data on excretion into breast milk were found.

Drug with poor scientific support which is marketed in very few countries.
Marketed as part of in many “at the counter” compounds in association poliasociación with expectorants, bronchodilators, antitussives, etc. Avoid the use of drug associations mostly while breastfeeding.

Although occasional and moderate use during lactation would probably not pose a serious risk, a safer alternative should be preferred until more data on this drug related to breastfeeding is available.

Topically used on the skin, it would not represent a risk during breastfeeding. Avoid applying it on the breast.

Assess the child for drowsiness and inappropriate infant feeding.
It is not recommended bed-sharing with your baby if you are on this medication.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Mepyramine acefyllinate
  • Mepyramine Hydrochloride
  • Mepyramine Maleate
  • Mepyramine tannate
  • Pyranisamine
  • Pyrilamine

Writings

  • μεπυραμίνη (Greek)
  • ميبيرامين (Arabic)
  • Мепирамин (Cyrillic)
  • 美吡拉敏 (Chinese)
  • C17H23N3O (Molecular formula)
  • メピラミン ()

Drug trade names

References

  1. UNICEF UK Baby Friendly Initiative statement on Bed-sharing when parents do not smoke: is there a risk of SIDS? An individual level analysis of five major case-control studies. 2013 Full text (link to original source) Full text (in our servers)
  2. Kalpaklioglu F, Baccioglu A. Efficacy and safety of H1-antihistamines: an update. Antiinflamm Antiallergy Agents Med Chem. 2012Abstract
  3. L.Landa Rivera, M.Díaz-Gómez, A.Gómez Papi, J.M.Paricio Talayero, C.Pallás Alonso, M.T.Hernández Aguilar, J.Aguayo Maldonado, J.M.Arena Ansotegui, S.Ares Segura, A.Jiménez Moya, J.J.Lasarte Velillas, J.Martín Calama, M.D.Romero Escós. El colecho favorece la práctica de la lactancia materna y no aumenta el riesgo de muerte súbita del lactante. Dormir con los padres. Rev Pediatr Aten Primaria. 14:53-60 2012 Full text (link to original source) Full text (in our servers)
  4. So M, Bozzo P, Inoue M, Einarson A. Safety of antihistamines during pregnancy and lactation. Can Fam Physician. 2010Abstract Full text (link to original source) Full text (in our servers)
  5. ABM - Comité de protocolos de la Academia médica de lactancia materna (Academy of Breastfeeding Medicine). Protocolo Clínico de la ABM #6: Lineamientos sobre la práctica de dormir al bebé junto con la madre y la lactancia materna Revisión, marzo de 2008. Breastfeeding Medicine 2008 Full text (link to original source) Full text (in our servers)
  6. ABM - The Academy of Breastfeeding Medicine Protocol Committee. ABM Clinical Protocol #6: Guideline on Co-Sleeping and Breastfeeding. Breastfeeding Medicine 2008Abstract Full text (link to original source) Full text (in our servers)
  7. AEMPS. Mepifilina. Ficha técnica. 2007 Full text (in our servers)
  8. Leimgruber A. [Treatment of asthma and rhinitis during pregnancy and breast feeding]. Rev Med Suisse. 2007Abstract
  9. Buhimschi CS. Endocrinology of lactation. Obstet Gynecol Clin North Am. 2004Abstract
  10. Solhaug V, Roland PD. [Use of antihistaminics during pregnancy and breast feeding]. Tidsskr Nor Laegeforen. 2004Abstract
  11. Ghaeli P, Kaufman MB. Oral antihistamines/decongestants and breastfeeding. J Hum Lact. 1993Abstract
  12. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993Abstract
  13. Messinis IE, Souvatzoglou A, Fais N, Lolis D. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985Abstract
  14. Pontiroli AE, De Castro e Silva E, Mazzoleni F, Alberetto M, Baio G, Pellicciotta G, De Pasqua A, Stella L, Girardi AM, Pozza G. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981Abstract