Is Felodipine compatible with breastfeeding? Do we have alternatives for Felodipine?

Felodipine

June 4, 2016 (Low Risk)

At latest update no published data were found on excretion into breast milk.

Evidence on other antihypertensive drugs of the same family with similar structure, pharmacokinetics and action profile (nifedipine, nimodipine, nicardipine) has shown that they are excreted into milk in non-significant amount.
Its high plasma protein binding capacity makes it highly unlikely a passage into milk.

It has been described an increased Prolactin plasma level and gynecomastia after using Felodipine.

Until more extensive published data about this drug regarding breastfeeding are available a safer alternative drug should be used, especially during the neonatal period and/or in case of premature infants.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • Φελοδιπίνη (Greek)
  • فيلوديبين (Arabic)
  • Фелодипин (Cyrillic)
  • 非洛地平 (Chinese)
  • フェロジピン (Japanese)
  • C18H19Cl2NO4 (Molecular formula)

References

  1. AEMPS. Felodipino. Ficha técncia. 2015 Full text (in our servers)
  2. Felodipine. Product Monograph. Sanofi-Aventis 2006 Full text (in our servers)
  3. Pan Y, Grindstaff A, Cassada D, Goldman M, Taylor J. Bilateral reduction mammoplasty in a patient treated with calcium channel blocker and cyclosporine after renal transplant: a case report. Transplantation. 1997Abstract