Felodipine
At latest update no published data were found on excretion into breast milk.
Evidence on other antihypertensive drugs of the same family with similar structure, pharmacokinetics and action profile (nifedipine, nimodipine, nicardipine) has shown that they are excreted into milk in non-significant amount.
Its high plasma protein binding capacity makes it highly unlikely a passage into milk.
It has been described an increased Prolactin plasma level and gynecomastia after using Felodipine.
Until more extensive published data about this drug regarding breastfeeding are available a safer alternative drug should be used, especially during the neonatal period and/or in case of premature infants.
Alternatives
- Nimodipine (Very Low Risk)
- Nifedipine (Very Low Risk)
- Nitrendipine (Very Low Risk)
- Verapamil Hydrochloride (Very Low Risk)
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Writings
- Φελοδιπίνη (Greek)
- فيلوديبين (Arabic)
- Фелодипин (Cyrillic)
- 非洛地平 (Chinese)
- フェロジピン (Japanese)
- C18H19Cl2NO4 (Molecular formula)
Drug trade names
References
- AEMPS. Felodipino. Ficha técncia. 2015 Full text (in our servers)
- Felodipine. Product Monograph. Sanofi-Aventis 2006 Full text (in our servers)
- Pan Y, Grindstaff A, Cassada D, Goldman M, Taylor J. Bilateral reduction mammoplasty in a patient treated with calcium channel blocker and cyclosporine after renal transplant: a case report. Transplantation. 1997Abstract