Is Morphine compatible with breastfeeding? Do we have alternatives for Morphine?

Morphine

July 2, 2015 (Low Risk)

Excretion into breast milk is low (even lower when administered through Epidural Anesthesia).

In addition, a low oral bioavailability makes that the amount present in the infant's plasma due to absorption from milk by the gut is low.

Even though, level of drug has been found in the plasma of infants from treated mothers, harmful effects in the infants were not reported.

Levels in the milk are lower and side-effects are fewer among infants whose mothers were treated with Morphine than with Pethidine.

Some authorities consider Morphine as the elective opioid medication for breastfeeding mothers.

Analgesia used during the birth process is related to a brief delayed of stage II of Lactogenesis (milk come-in).

Morphine increases Prolactin level and may decrease Oxytocin level, but it would not be determinant for already established lactations.

Avoidance of repetitive or chronic use and follow-up for somnolence and adequacy of infant nourishment is recommended.

Bed-sharing should be avoid whenever this medication is used by parents.

The American Academy of Pediatrics rates it as compatible with breastfeeding.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • Морфин (Cyrillic)
  • モルヒネ (Japanese)

Drug trade names

References

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