Is Vecuronium Bromide compatible with breastfeeding? Do we have alternatives for Vecuronium Bromide?

Vecuronium Bromide

January 4, 2015 (Low Risk)

It is a non-depolarizing muscle relaxant drug with a peripheral action that is used as premedication for endotracheal intubation, general anesthesia and mechanical ventilation.

At latest update, no relevant published data concerning excretion into breast milk were found.

Because a relatively high molecular-weight and a high protein-binding capacity, excretion into breast milk is thought to be low. It has a low oral bioavailability which means that absorption from the breast milk ingested may be low.

Vecuronium should not prevent a mother from breast feeding her baby shortly after recovering from an anesthesia if she is in good condition.

However, other muscle relaxants with a more rapid elimination time period and better known drugs are preferred.

List of Essential Medicines WHO 2002: Compatible with breastfeeding.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Org-NC-45
  • بروميد فيكورونيوم
  • βεκουρόνιο βρωμιούχο
  • Векурония Бромид
  • 维库溴铵
  • ベクロニウム臭化物

Drug trade names

References

  1. Dalal PG, Bosak J, Berlin C. Safety of the breast-feeding infant after maternal anesthesia. Paediatr Anaesth. 2014Abstract
  2. NZDS. Vecuronium. Drug Summary. 2014 Full text (in our servers)
  3. AEMPS. Vecuronio. Ficha técnica. 2007 Full text (in our servers)
  4. Howie WO, McMullen PC. Breastfeeding problems following anesthetic administration. J Perinat Educ. 2006Abstract Full text (link to original source) Full text (in our servers)
  5. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  6. Ferriols Lisart R,Ferriols Lisart F. Farmacología clínica y usos terapéuticos del Mivacurio. Farm Hosp. 1997 Full text (in our servers)
  7. Spigset O. Anaesthetic agents and excretion in breast milk. Acta Anaesthesiol Scand. 1994Abstract
  8. Dailey PA, Fisher DM, Shnider SM, Baysinger CL, Shinohara Y, Miller RD, Abboud TK, Kim KC. Pharmacokinetics, placental transfer, and neonatal effects of vecuronium and pancuronium administered during cesarean section. Anesthesiology. 1984Abstract