Ethinylestradiol + Gestodene
Birth control pill that contains the combination of an estrogen (Ethinyl estradiol) and a progestin (Gestodene) for oral use.
ETHINYLESTRADIOL is a synthetic estrogen with similar action than estradiol. Used in combination with progestogens for contraception.
Ethinylestradiol is excreted into the breast milk in no or small amount.
There is evidence (albeit inconsistent) that estrogen-containing pills may decrease milk production, especially during the first few weeks postpartum with a daily dose above 30 micrograms of ethinyl estradiol.
It may reduce the protein content of the milk.
No problems have been observed in infants whose mothers were treated, except some cases of transient gynecomastia in infants whose mothers were receiving a higher dose than usual.
GESTODENE is a progestin with structure similar to levonorgestrel (derived from nortestosterone).
Since the last update we have not found published data on its excretion in breast milk.
Its high percentage of protein binding makes it very unlikely that milk will pass through significant amounts, as occurs with levonogestrel (Shenfield 1991).
With other similar combined contraceptives no differences have been observed in the frequency of breastfeeding or the amount of milk produced or weight gain of breastfed infants compared to other contraceptive methods (intrauterine devices, isolated progestogens). However, it would be advisable to avoid them until breastfeeding is well established (4-6 weeks).
During lactation, progestin-only contraceptive pills are preferred to Estrogen containing ones, otherwise, the lowest estrogen dose should be used.
During the first 6 postpartum weeks, non-hormonal methods are in the first line of choice.
Hormone containing contraceptives do not affect the composition of milk, minerals (Mg, Fe, Cu, Ca, P) fat, lactose and calories but only a few the proteins.
Alternatives
- Desogestrel (Very Low Risk)
- Ethinylestradiol + Levonorgestrel (Low Risk probable)
- Levonorgestrel (Very Low Risk)
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Writings
- Αιθυνυλοιστραδιόλη + Γεστοδένη (Greek)
- جاستودان + إيثينيلإيستراديول (Arabic)
- Этинилэстрадиол + Гестоден (Cyrillic)
- 炔雌醇 + 孕二烯酮 (Chinese)
- エチニルエストラジオール + ゲストデン (Japanese)
- C20H24O2 + C21H26O2 (Molecular formula)
- G03AA10 (ATC Code/s)
Drug trade names
References
- AEMPS. Gestodeno y Etinilestradiol. Ficha técnica. 2015 Full text (in our servers)
- ARTG. Gestodene and Ethinyloestradiol (Minulet). Drug Summary. 2004
- Shenfield GM, Griffin JM. Clinical pharmacokinetics of contraceptive steroids. An update. Clin Pharmacokinet. 1991Abstract